Quantitative Imaging

Bone Structure Evaluation

The bone is a complex tissue which regulates its mass and architecture to satisfy the structural and metabolic necessities. The bone structure the body framework and it serves as a mineral reservoir. Our Micro-CT system has been extensively used to scan bone structures. Our home built detectors provide extremely high resolution and sensitivity unmatched by current flat panel technologies. We provided vital data to research groups working in dentistry, regenerative materials, implants and ageing. In addition to raw data we developed software which can calculate various morphological parameters such as: bone surface, trabecular volume, trabecular thickness, trabecular separation number and fractal dimension.


  • Femur of a mouse, 7 micron voxel size. Volumes are used to calculate parameters such as: Bone Volume/Total Volume, Trabecular Thickness, Trabecular Number, Trabecular Space, etc.



Parametric Imaging

Parametric imaging, also referred to as colored coded DSA, is done by analyzing the contrast behavior at each pixel in the image. Since the early development of DSA there were many attempts to incorporate the temporal information of the contrast propagation. Such temporal information could be used to create a blood flow parametric description over the entire imaged vasculature. Despite these attempts this imaging processing method did not become clinical reality. The delays were due to various considerations such as computational speed, flow dependence on injection technique or limited knowledge of flow parameters with the patient physiology. The computational aspect meanwhile has been addressed using advanced hardware and advanced programming techniques. The value of individual pixels is tracked in each frame and a time density curve is built. Each curve is analyzed and curve parameters are calculated at each pixel. Various matrices containing parameters such as TTP, MTT, Arrival Time etc. can be calculated and later displayed using a colored mapping convention.


Parametric images showing Bolus Arrival Time, Mean Transit Time and Time to Peak in a 3D printed phantoms of Circle of Willis With aneurysms.

Research Focus

Ciprian Ionita Ph.D., heads the quantitative imaging group at the Toshiba Stroke and Vascular Research Center.

The team developed various micro-CT systems based on micro-angiographic detectors. These systems have very high resolution (~8 μm) and low electronic noise which alow usage at very low x-ray doses. Most of the applications are focused on small samples and small tissue sample.

Over the years Dr. Ionita developed many software for analysis of the medical images which could be used for calculations of: bone density, object volume. fractal dimension or contrast flow estimation.